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KMID : 0616120160470030226
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Korean Journal of Pharmacognosy
2016 Volume.47 No. 3 p.226 ~ p.231
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Composition and Anti-cholinesterase Activity of the Essential Oil Obtained from Korean Elsholtzia ciliata
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Song Byong-Min
Choi Jae-sue
Park Hee-Juhn
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Abstract
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The present GC-MS analysis elucidated the composition of the essential oil obtained from the herb of Elsholtzia ciliata(Lamiaceae). Overall, the content of monoterpenes was higher than that of sesquiterpenes. Monoterpenes rich in this oil were carvone (peak area, 26.180%), camphor (2.304%), borneol (9.974%), dihydrocarveol (3.296%), a-citral (=geranial, 4.025%), geranic acid (2.961%), while sesquiterpenes occupying relatively higher percentage were a-humulene (0.918%), (-)-spathulenol (0.974%), a-caryophyllene oxide (2.014%), globulol (1.362%), b-caryophyllene oxide (0.750%). The components characterizing this oil were 1-octen-3-ol, acetophenone, and butylated hydroxytoluene. The IC50 of this oil on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) were 42.37 μg/ml and 121.34 μg/ml, respectively, suggesting that the essential oil of E. ciliata may be active on the memory loss of patients suffering from Alzheimer’s disease.
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KEYWORD
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Elsholtzia ciliata, Lamiaceae, Essential oil, Carvone, Acetylcholinesterase
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